Profound metabolic changes occur hand-in-hand with activation of macrophages, innate immune cells responsible for a remarkable breadth of processes such as pathogen elimination, antigen presentation, debris clearance, and wound healing. Our work seeks to define precisely how mitochondrial metabolism directly affects innate immunity, and exactly which features of macrophage activation are controlled by this metabolic reprogramming.
Related Publications
Jones AE and Divakaruni AS§ (2020) Macrophage activation as an archetype of mitochondrial repurposing. Molecular Aspects of Medicine. 71:100838. 31954522
Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, and Berod L (2018) Etomoxir actions on regulatory and memory T Cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metabolism. 28(3):504-15. 30043753
Divakaruni AS*§, Hsieh WY*, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, and Murphy AN (2018) Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis. Cell Metabolism. 28(3):490-503. 30043752
Ball AB, Jones AE, Nguyễn KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, and Divakaruni AS. (2025) Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation. EMBO Reports. 26(4):982-1002. 39753784
Jones AE, Rios A, Ibrahimovic N, Chavez C, Bayley NA, Ball AB, Hsieh WY, Sammarco A, Bianchi AR, Cortez AA, Graeber TG, Hoffmann A, Bensinger SJ, and Divakaruni AS. (2024) The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling. bioRxiv [Preprint]. 2024.03.28.587096. 38585887
