*denotes equal contribution | §denotes corresponding author |authors from our laboratory are in bold
Li JH, Zhou A, Lee CD, Shah SN, Ji JH, Senthilkumar V, Padilla ET, Ball AB, Feng Q, Bustillos GC, Riggan L, Greige A, Divakaruni AS, Annese F, Cooley Coleman JA, Skinner SA, Cowan CW, O'Sullivan TE (2024) MEF2C regulates NK cell effector functions through control of lipid metabolism Nature Immunology. 25(5):778-789. 38589619
Ball AB, Jones AE, Nguyễn KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. (2024) Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration bioRxiv [Preprint]. 2024.05.10.593451. 38798678
Jones AE, Rios A, Ibrahimovic N, Chavez C, Bayley NA, Ball AB, Hsieh WY, Sammarco A, Bianchi AR, Cortez AA, Graeber TG, Hoffmann A, Bensinger SJ, Divakaruni AS. (2024) The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling bioRxiv [Preprint]. 2024.03.28.587096. 38585887
Ollivier M, Soto JS, Linke KE, Moye SL, Jami-Alahmadi Y, Jones AE, Divakaruni AS, Kawaguchi R, Wohlschlegel JA, Khakh BS. (2024) Crym-positive striatal astrocytes gate perseverative behaviour Nature. 627(8003):358-366. 38418885
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS . (2024) The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. Journal of Biological Chemistry. 300(3):105702. 38301896
Crowell PD, Giafaglione JM, Jones AE...Divakaruni AS, Goldstein AS. (2023) MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Reports. 42(10):113221 37815914
Cao D, Saito S, Xu L, Fan W, Li X, Ahmed F, Jovanovic P, Shibata T, Che M, Bernstein EA, Gianni J, Divakaruni AS, Okwan-Duodu D, Khan Z, Riera CE, Chen F, Bernstein KE. (2023) Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis Frontiers in Immunology Oct 20:14:1278383. 37928535
DeSousa BR, Kim KO, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein A, Ferrick D, Shirihai OS, Neilson A, Nathanson D, Rogers G, Drank B, Murphy A, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. (2023) Calculation of ATP production rates using the Seahorse XF Analyzer EMBO Reports. 24(10):e56380 37548091
Cao D, Khan Z, Li X, Saito S, Bernstein EA, Victor AR, Ahmed F, Hoshi AO, Veiras LC, Shibata T, Che M, Cai L, Temel RE, Giani JF, Luthringer DJ, Divakaruni AS, Okwan-Duodu D, Bernstein KE. (2023) Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor alpha and fundamentally changing lipid metabolism. Cardiovascular Research 119(9):1825-1841. 37225143
Yan T, Julio AR, Villanueva M, Jones AE, Ball AB, Boatner LM, Turmon AC, Nguyễn KB, Yen SL, Desai HS, Divakaruni AS, & Backus KM. (2023) Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. Cell Chemical Biology. 30(7):811-827.e7 37419112
Acín-Pérez R, Montales KP, Nguyen KB, Brownstein AJ, Stiles L, Divakaruni AS. (2023) Isolation of mitochondria from mouse tissues for functional analysis. Methods Molecular Biology 2675:77-96. 37258757
Ngo J, Choi DW, Stanley IA, Stiles L, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Lisa M, Danial NN, Shirihai OS. (2023) Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO 42(11):e111901. 36917141
Fernandez-Del-rio L, Benincá C, Villalobos F, Shu C, Stiles L, Liesa M, Divakaruni AS, Acin-Perez R, Shirihai OS. (2023) A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates. Life Science Alliance 6(4):e202201628. 36918278
Hazim RA, Paniagua AE, Tang L, Yang Y, Kim KKO, Stiles L, Divakaruni AS, Williams DS. (2022) Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. Journal of Biological Chemistry. 298(9): 102286
Divakaruni AS, Jastroch M. (2022) A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements. Nature Metabolism. 4, 978-994
Meriwether D, Jones AE, Ashby JW, Solorzano-Vargas RS, Dorreh N, Noori S, Grijalva V, Ball AB, Semis M, Divakaruni AS, Mack JJ, Herschman HR, Martin MG, Fogelman AM, Reddy ST (2022) Macrophage COX2 mediates efferocytosis, resolution reprogramming, and intestinal epithelial repair. Cellular and Molecular Gastroenterology and Hepatology. 13(4): 1095-1120. 35017061
Yang K, Doan MT, Stiles L, and Divakaruni AS (2021) Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria. STAR Protocols. 2: 100687. 34401773
Jacques V, Bolze S, Hallakou-Bozec S, Czarnik AW, Divakaruni AS, Fouqueray P, Murphy AN, Van der Ploeg LHT, and DeWitt S (2021) Deuterium-stabilized (R)-pioglitazone (PXL065) is responsible for pioglitazone efficacy in NASH yet exhibits little to no PPARγ activity. Hepatology Communications. 34430785
Jones AE, Arias NJ, Acevedo A, Reddy ST, Divakaruni AS*§, and Meriwether D*§ (2021) A single LC-MS/MS analysis to quantify CoA biosynthetic intermediates and short-chain acyl CoAs. Metabolites. 11(8): 468. 34436409
Tucci J, Chen T, Margulis K, Orgel E, Paszkiewicz RL, Cohen MD, Oberley MJ, Wahhab R, Jones AE, Divakaruni AS, Hsu CC, Noll SE, Sheng X, Zare RN, and Mittelman SD (2021) Adipocytes provide fatty acids to acute lymphoblastic leukemia cells. Frontiers in Oncology. 11: 665763. 33968771
Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein A, Desousa BR, Acín-Pérez R, Petcherski A, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, and Shirihai OS (2021) Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat. EMBO Reports. 21(12): e49634. 33275313
Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, and Divakaruni AS (2021) Forces, fluxes, and fuels: Tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. AJP Cell Physiology. 320(1): C80-C91. 33147057
Krishnan KC, Floyd RR, Sabir S, Jayasekera DW, Jones AE, Cortez AA, Anum DC, Shravah V, Péterfy M, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, and Lusis AJ (2021) Liver pyruvate kinase promotes NAFLD/NADH in both mice and humans in a sex-specific manner. Cellular and Molecular Gastroenterology and Hepatology. 11(2): 389-406. 32942044
Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk HR, Castro MG, Lowenstein PR, Le Belle JE, and Kornblum HI (2020) Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet Therapy. iScience. 23(9): 101453. 32861192
Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, and Bensinger SJ (2020) Toll-like receptors induce signal-specific reprogramming of the macrophage lipidome. Cell Metabolism. S1550-4131(20): 30242-4. 32516576
Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, and Shirihai OS (2020) A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO Journal. 39(13): e104073. 32432379
Jones AE and Divakaruni AS§ (2020) Macrophage activation as an archetype of mitochondrial repurposing. Molecular Aspects of Medicine. 71:100838. 31954522
Cao DY, Spivia WR, Veiras LC, Khan Z, Peng Z, Jones AE, Bernstein EA, Saito S, Okwan-Duodu D, Parker SJ, Giani JF, Divakaruni AS, Van Eyk JE, and Bernstein KE (2020) ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP. Journal of Biological Chemistry. 295(5):1369-1384. 31871049
Divakaruni AS§ and Murphy AN§ (2020) Do two mitochondrial wrongs help make cells right? Trends in Molecular Medicine. 26(1) :3-6. 31813762
Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, and Berod L (2018) Etomoxir actions on regulatory and memory T Cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metabolism. 28(3):504-15. 30043753
Divakaruni AS*§, Hsieh WY*, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, and Murphy AN (2018) Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis. Cell Metabolism. 28(3):490-503. 30043752
Divakaruni AS§, Andreyev AY, Rogers GW, and Murphy AN (2018) In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Analytical Biochemistry. 552:60-65. 28987935